LOVASTATIN-INDUCED MITOCHONDRIAL OXIDATIVE STRESS LEADS TO THE RELEASE OF MTDNA TO PROMOTE APOPTOSIS BY ACTIVATING CGAS-STING PATHWAY IN HUMAN COLORECTAL CANCER CELLS

Statins are 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors widely used in the treatment of hyperlipidemia.The inhibition of HMG-CoA reductase in the mevalonate pathway leads to the suppression of cell proliferation and induction of apoptosis.The cyclic GMP-AMP synthase (cGAS) stimulator of the interferon genes (STING) signalin

The viability and competitiveness of Staphylococcus xylosus in meat mostly depend on the ability to adapt itself to rapid oxygen and nutrients depletion during meat fermentation.The utilization of nitrite instead of oxygen becomes a successful strategy for this strain to improve its performance in anaerobiosis; however, metabolic pathways of this s

Wilms′ tumor (WT) represents 6% of childhood cancers.Recent advances in molecular biology have significant implications for SUPERMOUSSE the clinical management.A dramatic improvement in overall cure has resulted from the adoption of multimodality treatment during the past few decades.National Wilms′ Tumor Study (NWTS), and the

The aim of this paper is to investigate some fixed and co-incidence point theorems in complete, orbitally Angle Grinder Nut complete and (T, f)-orbitally complete partial metric spaces under the generalized contractive type conditions of mappings.Moreover, our results generalize and extend the several obtained results in the literature.Additionally